Table 8 Biclusters containing the miR-17-92 gene cluster family
ID | miRNAs | mRNAs | miRNA GC | p MF | p BP | q |
|---|---|---|---|---|---|---|
Hierarchy level 2 | ||||||
6 | mir-17, mir-20a | APP, BCL2, BMPR2, CCND1, CCND2, CDKN1A, E2F1, E2F3, MAP3K12, MAPK9, MEF2D, MYC, PTEN, RB1, RBL1, RBL2, RUNX1, SMAD4, TGFBR2, THBS1, VEGFA, WEE1 | miR-17-92 | 3.96 E-6 | 3.37 E-7 | 1.0 |
22 | mir-93, mir-106b | CDKN1A, E2F1, KAT2B, MAPK9, VEGFA | miR-106b-25 | 1.00 | 1.30 E-6 | 1.0 |
31 | mir-20b, mir-106a | ARID4B, CDKN1A, HIPK3, MYLIP, VEGFA | miR-106a-363 | 1.00 | 1.00 | 1.0 |
58 | mir-17, mir-21, mir-18a, mir-19b | NCOA3, PTEN | miR-17-92 | 1.00 | 1.00 | 1.0 |
66 | mir-17, mir-19a, mir-20a, mir-92a | BMPR2, SMAD4, TGFBR2 | miR-17-92 | 5.53 E-41 | 3.23 E-31 | 1.0 |
67 | mir-19b, mir-20b, mir-92a, mir-106a | ARID4B, HIPK3, MYLIP | miR-17-92, miR106a-363 | 1.00 | 0.03 | 1.0 |
70 | mir-17, mir-20a, mir-106a | CDKN1A, E2F1, RB1, RUNX1, VEGFA | miR-17-92, miR106a-363 | 5.77 E-4 | 1.99 E-9 | 1.0 |
72 | mir-17, mir-20a, mir-106b | APP, CCND2, E2F3, MAPK9, RBL1, RBL2, WEE1 | miR-17-92, miR-106b-25 | 1.00 | 5.00 E-24 | 1.0 |
Hierarchy level 2 | ||||||
6-72 | mir-17, mir-20a, mir-106b | APP, BCL2, BMPR2, CCND1, CCND2, CDKN1A, E2F1, E2F3, MAP3K12, MAPK9, MEF2D, MYC, PTEN, RB1, RBL1, RBL2, RUNX1, SMAD4, TGFBR2, THBS1, VEGFA, WEE1 | miR-17-92, miR106b-25 | 1.90 E-5 | 6.46 E-5 | 0.8 |
22-70 | mir-17, mir-93, mir-20a, mir-106a, mir-106b | CDKN1A, E2F1, KAT2B, MAPK9, RB1, RUNX1, VEGFA | miR-17-92, miR-106b-25, miR106a-363 | 1.60 E-5 | 1.07 E-7 | 0.8 |
58-66 | mir-17, mir-21, mir-18a, mir-19a, mir-19b, mir-20a, mir-92a | BMPR2, NCOA3, PTEN, SMAD4, TGFBR2 | miR-17-92 | 3.18 E-9 | 1.30 E-8 | 0.8 |
Hierarchy level 3 | ||||||
6-72-22-70 | mir-17, mir-93, mir-20a, mir-106a, mir-106b | APP, BCL2, BMPR2, CCND1, CCND2, CDKN1A, E2F1, E2F3, KAT2B, MAP3K12, MAPK9, MEF2D, MYC, PTEN, RB1, RBL1, RBL2, RUNX1, SMAD4, TGFBR2, THBS1, VEGFA, WEE1 | miR-17-92, miR-106b-25, miR106a-363 | 2.46 E-4 | 1.56 E-4 | 0.6 |