ConSole: using modularity of Contact maps to locate Solenoid domains in protein structures

BMC Bioinformatics

Table 1 Benchmark results of various solenoid classifiers

	Rule based		Rule based		ConSole		ConSole		Raphael S > 0	Raphael S > 1
	Residue		Structure		Residue		Structure		Structure	Structure
	Sol.	NSol.	Sol.	NSol.	Sol.	NSol.	Sol.	NSol.	Sol.	Sol.
Sensitivity	74%	40%	55%	88%	72%	88%	87%	100%	89%	93%
Precision	89%	19%	65%	83%	66%	90%	100%	95%	86%	98%
Accuracy	69%		79%		84%		96%		94%	96%
MCC	0.11		0.46		0.59		0.91		0.87	0.89

Evaluation of solenoid/non-solenoid classification accuracies determined for all solenoid classifiers mentioned. Sensitivity, precision, accuracy, and MCC were determined on a standard benchmark dataset of 105 solenoid (Sol.) and 243 non-solenoid (NSol.) protein structures. Results were determined either for individual residues (Residue level) or for whole structures (Structure level).

ISSN: 1471-2105