From: Exploiting large-scale drug-protein interaction information for computational drug repurposing
With SEA | Without SEA | ||||
---|---|---|---|---|---|
Evaluation of top-ranking scores (%) | Drugs in training set | Fraction | σ | Fraction | σ |
High Blood Pressure model | |||||
1 | 1 | 0.14 | 0.06 | 0.15 | 0.07 |
5 | 1 | 0.36 | 0.11 | 0.36 | 0.11 |
10 | 1 | 0.50 | 0.14 | 0.48 | 0.14 |
1 | 2 | 0.14 | 0.06 | 0.18 | 0.07 |
5 | 2 | 0.48 | 0.09 | 0.45 | 0.10 |
10 | 2 | 0.64 | 0.09 | 0.60 | 0.11 |
1 | 3 | 0.19 | 0.06 | 0.20 | 0.07 |
5 | 3 | 0.53 | 0.08 | 0.52 | 0.10 |
10 | 3 | 0.70 | 0.08 | 0.67 | 0.10 |
HIV model | |||||
1 | 1 | 0.16 | 0.09 | 0.20 | 0.19 |
5 | 1 | 0.28 | 0.14 | 0.30 | 0.18 |
10 | 1 | 0.37 | 0.17 | 0.39 | 0.21 |
1 | 2 | 0.17 | 0.07 | 0.18 | 0.07 |
5 | 2 | 0.32 | 0.12 | 0.33 | 0.10 |
10 | 2 | 0.44 | 0.13 | 0.43 | 0.15 |
1 | 3 | 0.19 | 0.07 | 0.21 | 0.07 |
5 | 3 | 0.34 | 0.11 | 0.37 | 0.09 |
10 | 3 | 0.48 | 0.10 | 0.50 | 0.12 |
Malaria model | |||||
1 | 1 | 0.14 | 0.07 | 0.20 | 0.24 |
5 | 1 | 0.34 | 0.14 | 0.54 | 0.25 |
10 | 1 | 0.70 | 0.22 | 0.79 | 0.22 |
1 | 2 | 0.20 | 0.13 | 0.20 | 0.13 |
5 | 2 | 0.43 | 0.20 | 0.58 | 0.16 |
10 | 2 | 0.73 | 0.15 | 0.89 | 0.10 |
1 | 3 | 0.21 | 0.09 | 0.21 | 0.10 |
5 | 3 | 0.49 | 0.15 | 0.66 | 0.13 |
10 | 3 | 0.77 | 0.13 | 0.91 | 0.07 |