From: Exploiting large-scale drug-protein interaction information for computational drug repurposing
Generic name | Score | Information from DrugBankb | Information from other sources |
---|---|---|---|
Nitrendipine | 103.9 | For mild to moderate hypertension. | |
Nimodipine | 93.9 | For use as an adjunct to improve neurologic outcome following subarachnoid hemorrhage. | A 1998 clinical study [33] observed that nimodipine reduces systolic and diastolic blood pressures of the central retinal artery and therefore may provide another therapeutic choice for pregnancy-induced hypertension. |
Alprenolol | 69.7 | For hypertension, angina, and arrhythmia. | |
Nilvadipine | 69.2 | For vasospastic angina, chronic stable angina, and hypertension. | |
Oxprenolol | 69.1 | For the treatment of hypertension, angina pectoris, arrhythmias, and anxiety. | |
Norepinephrine | 53.8 | For patients in vasodilatory shock states, also used as a vasopressor medication for patients with critical hypotension. | |
Spirapril | 52.1 | An ACE inhibitor for hypertension. | |
Lercanidipine | 46.5 | For hypertension, angina pectoris, and Raynaud’s syndrome. | |
Yohimbine | 44.7 | Used as a mydriatic and for the treatment of impotence. | |
Epinephrine | 43.9 | Used in asthma and cardiac failure and to delay absorption of local anesthetics. | A systematic review in 2002 [34] found that the use of epinephrine in uncontrolled hypertensive patients was associated with small, non-significant increases in systolic and diastolic blood pressure. |