Figure 4

The results of CoMDP on the GBM1 dataset with k =10. (A) The co-occurrence between the two gene sets {CDKN2A, PTEN, CYP27B1, KDR, WT1} and {CDKN2B, NF1, RB1, CDK4, ERBB2}. (B) Several pathways are involved, including the p53, PI3K/Akt, RTK/RAS/ERK, RB and RTK/RAS/PI3K signaling pathways. The line between p53 and WT1 denotes they are physically interacted, whereas the double lines between KRAS and CDK4 represents sometimes there is a synthetic lethal interaction between them. The green and blue nodes denote the genes involved in the two detected co-occurring gene sets. The regulatory relations are extracted from the KEGG database and related literature.