CRF-based models of protein surfaces improve protein-protein interaction site predictions

BMC Bioinformatics

Table 2 Comparing the enhancer with the threshold classifier of approximately equal specificity on synthetic scores assigned to surface residues of protein complexes taken from the data set PlaneDimers and the KL-subset

Data Set	Score Precisionς	Classifier	Specificity	Sensitivity	MCC
	0.8	Threshold Predictor	0.9672	0.2562	0.3253
	0.8	Enhancer	0.9666	0.4281	0.4911
PlaneDimer	0.9	Threshold Predictor	0.9618	0.2556	0.3077
	0.9	Enhancer	0.9624	0.4086	0.4610
	1.0	Threshold Predictor	0.9611	0.2428	0.2912
	1.0	Enhancer	0.9612	0.3872	0.4379
	1.1	Threshold Predictor	0.9681	0.2100	0.2753
	1.1	Enhancer	0.9677	0.3307	0.4045
	1.2	Threshold Predictor	0.9649	0.2100	0.2648
	1.2	Enhancer	0.9647	0.3213	0.3854
	0.8	Threshold Predictor	0.9568	0.2936	0.3549
	0.8	Enhancer	0.9577	0.3586	0.4210
KL-subset	0.9	Threshold Predictor	0.9533	0.2843	0.3369
	0.9	Enhancer	0.9531	0.3290	0.3820
	1.0	Threshold Predictor	0.9570	0.2559	0.3152
	1.0	Enhancer	0.9571	0.2971	0.3591
	1.1	Threshold Predictor	0.9615	0.2279	0.2949
	1.1	Enhancer	0.9614	0.2743	0.3459
	1.2	Threshold Predictor	0.9604	0.2199	0.2828
	1.2	Enhancer	0.9599	0.2516	0.3175

ISSN: 1471-2105