Data | Annotation- | Function- | Topology- |
|---|
| | based | based | based |
|---|
F/G | 0.7224 ± 0.0010 | 0.6781 ± 0.0001 | 0.6863 ± 0.0009 |
| | (0.4945) | (0.4968) | (0.5005) |
Common | 0.7527 ± 0.0010 | 0.7147 ± 0.0001 | 0.7555 ± 0.0020 |
| | (0.4926) | (0.5005) | (0.4951) |
- Numbers in the table are AUC values obtained by evaluating the three disease similarity measures against disease associations derived from highly confident GWAS data. Only diseases annotated with at least 3 genes were evaluated. ‘F/G’ are diseases having associated genes in both FunDO and GWAS data (99 diseases in total). ‘Common’ are diseases having associated genes in all four disease-gene association datasets (given in Figure 1) and GWAS data (50 diseases in total). Average AUC values obtained by using randomised scores are shown by numbers in brackets (standard deviations are not shown in the table due to space limitation). Each evaluation test was run 30 times to compute the statistics reported in the table.
