Figure 4

Driver analysis over extended chromosomal regions. All the components of NEA were run over copy-number altered regions of chromosome 7 in the ovarian cancer. The grey areas mask the chromosomal regions omitted from this plot, so that only four selected regions are shown. Multi-colored bars in the lower plot indicate the copy numbers in individual OV genomes relative to the reference diploid genome (dotted red line). Grey lines indicate the 10^th, 25^th, 50^th, 75^th, and 90^th percentiles of copy number in the OV cohort. The upper plot shows the prioritization of genes based on the–log₁₀ of their combined p-values: genes with higher positions are more highly prioritized. Genes found to be highly significant in the 1-vs-CPW analysis are highlighted in red, those highly significant in the 1CNA-vs-MGS analysis are marked with a black asterisk, and red asterisks indicate genes highly significant in both analyses. Gene symbols in brackets indicate point mutations that co-occurred with the driver CNAs. A complete version of this figure can be found in the Additional file 2 and Additional file 3: GBM.CNA_drivers_along_chromosomes.pdf and OV.CNA_drivers_along_chromosomes.pdf.