Bioinformatics analysis of transcriptional regulation of circadian genes in rat liver

BMC Bioinformatics

Table 2 Putative clock TFs involved in the transcriptional regulation of circadian-relevant genes

Circadian patterns	Sets of regulators	p-value \| q-value	Sets of regulators	p-value \| q-value
1 109/132 genes^*	CREB, RORA, STAT	0.0078 \| 0.0616	FKHD, PARF, RXRF	0.0377 \| 0.0877
	CREB, RORA, RXRF	0.0116 \| 0.0616	RORA, RXRF, STAT	0.0409 \| 0.0877
	PARF, RORA	0.0191 \| 0.0753	CREB, FKHD, RORA	0.0473 \| 0.0877
2 27/42 genes	AHRR, CREB, STAT	0.0077 \| 0.0616	EBOX, CLOCK:BMAL1	0.0303 \| 0.0877
	AHRR, CREB, EBOX	0.0079 \| 0.0616	AHRR, RXRF, STAT	0.0327 \| 0.0877
	AHRR, CREB, KLFS, RXRF	0.0130 \| 0.0616	AHRR, KLFS, STAT	0.0482 \| 0.0877
3 39/46 genes	CREB, EBOX, RXRF, STAT	0.0428 \| 0.0877
4 59/70 genes	None

^*:number of genes with promoter information vs. the total number of genes in the group.

ISSN: 1471-2105