Figure 1From: A graph theoretic approach to utilizing protein structure to identify non-random somatic mutationsAn example protein with three different domains. Under iPAC, the Domain A residues will influence the final positions of Domain C residues and vice versa, a result that is undesirable if the three domains are independent of each other. The residues in Domain A and Domain C will have no effect on each other’s final position via the graph theoretic approach.Back to article page