From: A graph theoretic approach to utilizing protein structure to identify non-random somatic mutations
 | GraphPAC | iPAC | NMC | |||
---|---|---|---|---|---|---|
Protein | p-value | p* | p-value | p* | p-value | p* |
KRAS | 4.21 E-233 | 4.33 E-229 | 6.17 E-185 | 6.35 E-181 | 4.39 E-233 | 4.52 E-229 |
TP53 | 4.05 E-152 | 4.48 E-147 | 5.23 E-128 | 6.11 E-123 | 4.37 E-086 | 5.30 E-081 |
BRAF | 3.84 E-130 | 1.04 E-126 | 3.73 E-130 | 1.01 E-126 | 3.84 E-130 | 1.04 E-126 |
PIK3CA | 8.20 E-084 | 3.58 E-080 | 8.20 E-084 | 3.58 E-080 | 8.20 E-084 | 3.58 E-080 |
NRAS | 8.26 E-029 | 9.91 E-027 | 5.38 E-026 | 6.46 E-024 | 8.26 E-029 | 9.91 E-027 |
HRAS | 1.54 E-014 | 6.94 E-013 | 1.23 E-010 | 5.54 E-009 | 5.61 E-010 | 8.42 E-009 |
AKT1 | 2.47 E-005 | 2.47 E-004 | 1.18 E-005 | 7.08 E-005 | 2.47 E-005 | 7.41 E-005 |
IDE | 1.56 E-003 | 4.67 E-003 | 2.20 E-005 | 6.60 E-005 | 1.56 E-003 | 4.67 E-003 |
EGFR | 9.04 E-004 | 9.04 E-003 | 1.35 E-004 | 1.35 E-003 | - | - |
DPP4 | 3.17 E-003 | 3.63 E-002 | - | - | - | - |
MAP2K4 | 1.21E-003 | 1.21E-002 | - | - | - | - |
NRP1 | 1.58E-002 | 1.58E-002 | - | - | - | - |
PCSK9 | 5.61 E-003 | 1.68E-002 | - | - | - | - |
HAO1 | - | - | 7.95 E-003 | 2.39 E-002 | - | - |
EIF2AK2 | - | - | 2.45 E-003 | 7.36 E-003 | - | - |