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Figure 1 | BMC Bioinformatics

Figure 1

From: TOPS: a versatile software tool for statistical analysis and visualization of combinatorial gene-gene and gene-drug interaction screens

Figure 1

Overview of the two discussed multiplexing technologies used for gene-drug and gene-gene interaction studies. (A) Luminex multiplexing for a gene-drug interaction screen. The gene perturbation is multiplexed and encoded as a DNA barcode that can be hybridized to Luminex beads and quantified. Drugs are not multiplexed. (B) MPS double multiplexing screen for gene-gene interactions. The first (genetic) perturbation can be multiplexed as a Illumina index barcode, and the second perturbation is identified by sequencing the hairpin cassette, which acts as a second DNA barcode.

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BMC Bioinformatics

ISSN: 1471-2105

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