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Table 2 Results of MT applied to 3 NGS short-read alignment programs ran on the paired-end and single end sequencing reads of HapMap sample NA12872.

From: Verification and validation of bioinformatics software without a gold standard: a case study of BWA and Bowtie

MRs

BWA

BOWTIE

BOWTIE2

Paired-end sequencing reads

MR1

F

  

MR2

F

F

F

MR3

F

  

MR4

F

  

MR5

F

F

F

MR6

   

MR7

F

  

MR8

 

F

F

MR9

F

 

F

Single-end sequencing reads

MR1

F

  

MR2

F

F

F

MR3

F

  

MR4

   

MR5

F

F

F

MR6

   

MR7

   

MR8

 

F

F

MR9

F

 

F

  1. F (Failure).