From: Mining hidden knowledge for drug safety assessment: topic modeling of LiverTox as a case study
Known ALF drugs | 1st topic | 2nd topic | 3rd topic | 4th topic | ||||
---|---|---|---|---|---|---|---|---|
 | Topic ID | Prob. | Topic ID | Prob. | Topic ID | Prob. | Topic ID | Prob. |
Acetaminophen | 37 | 4.7E-01 | 29 | 3.6E-01 | 4 | 1.4E-01 | 6 | 1.6E-02 |
Amoxicillin/clavulanate | 37 | 6.3E-01 | 4 | 1.9E-01 | 15 | 1.2E-01 | 20 | 6.1E-02 |
Atorvastatin | 31 | 8.3E-01 | 39 | 1.7E-01 | 40 | 3.3E-05 | 38 | 3.3E-05 |
Benzbromarone* | 28 | 4.4E-01 | 37 | 4.2E-01 | 11 | 1.4E-01 | 40 | 3.8E-05 |
Carbamazepine | 3 | 4.6E-01 | 35 | 3.5E-01 | 38 | 1.9E-01 | 40 | 6.7E-05 |
Ciprofloxacin | 15 | 7.7E-01 | 14 | 2.3E-01 | 40 | 2.8E-05 | 39 | 2.8E-05 |
Cyclophosphamide | 31 | 6.4E-01 | 19 | 2.9E-01 | 40 | 6.2E-02 | 39 | 5.2E-05 |
Dapsone | 7 | 8.0E-01 | 31 | 2.0E-01 | 40 | 3.3E-05 | 39 | 3.3E-05 |
Diclofenac | 37 | 8.0E-01 | 20 | 1.4E-01 | 23 | 3.3E-02 | 22 | 2.2E-02 |
Disulfiram | 37 | 3.6E-01 | 38 | 2.6E-01 | 28 | 2.2E-01 | 7 | 1.6E-01 |
Doxycycline | 37 | 5.9E-01 | 17 | 3.3E-01 | 22 | 7.2E-02 | 40 | 3.6E-05 |
Ethambutol | 28 | 3.9E-01 | 10 | 3.5E-01 | 7 | 1.7E-01 | 24 | 8.7E-02 |
Halothane | 23 | 7.1E-01 | 37 | 2.8E-01 | 16 | 6.5E-03 | 40 | 1.6E-05 |
Ibuprofen | 31 | 3.2E-01 | 21 | 2.9E-01 | 37 | 2.0E-01 | 16 | 1.3E-01 |
Isoniazid | 37 | 6.2E-01 | 23 | 1.2E-01 | 10 | 9.5E-02 | 16 | 6.7E-02 |
Methyldopa | 37 | 7.9E-01 | 20 | 2.1E-01 | 40 | 5.2E-05 | 39 | 5.2E-05 |
Naproxen | 37 | 6.2E-01 | 30 | 1.8E-01 | 20 | 1.6E-01 | 2 | 3.6E-02 |
Nefazodone | 37 | 4.2E-01 | 26 | 2.7E-01 | 24 | 1.8E-01 | 28 | 1.3E-01 |
Nitrofurantoin | 37 | 1.0E+00 | 40 | 4.6E-05 | 39 | 4.6E-05 | 38 | 4.6E-05 |
Phenytoin | 7 | 3.0E-01 | 37 | 2.5E-01 | 3 | 2.1E-01 | 35 | 1.6E-01 |
Simvastatin | 31 | 4.9E-01 | 37 | 4.4E-01 | 34 | 6.1E-02 | 26 | 1.0E-02 |
Sulfamethoxazole/ trimethoprim | 7 | 8.3E-01 | 28 | 1.7E-01 | 40 | 3.5E-05 | 39 | 3.5E-05 |
Sulfasalazine | 7 | 6.8E-01 | 37 | 3.2E-01 | 40 | 3.2E-05 | 39 | 3.2E-05 |
Tolcapone* | 37 | 6.4E-01 | 25 | 2.7E-01 | 3 | 8.7E-02 | 40 | 3.1E-05 |
Troglitazone* | 37 | 4.6E-01 | 31 | 4.2E-01 | 1 | 1.1E-01 | 40 | 2.2E-05 |
Valproate | 35 | 4.2E-01 | 38 | 3.1E-01 | 26 | 2.1E-01 | 14 | 5.2E-02 |