Table 5 HIV, SHIV, and SIV DNA vaccines
From: DNAVaxDB: the first web-based DNA vaccine database and its data analysis
# | DNA Vaccine | Antigen name(s) | Challenge: HIV/SHIV strain | DNA plasmid | Vaccination regimen | PMID (year) |
|---|---|---|---|---|---|---|
DNA vaccine alone | ||||||
1 | HIV DNA vaccine VlJns-tPA-gp120 | gp120 | HIV-1 | VlJns | DNA vaccine alone | 9127013 (1997) |
2 | HIV-2 DNA vaccine | gag, nef, tat, env | HIV-2UC2/9429 | pND-14 | DNA vaccine with GM-CSF and B7-2 adjuvants | 15149785 (2004) |
3 | SIV DNA vaccine encoding SIV core protein | Core protein | SHIV89.6P | pCSIVgag | DNA vaccine with IL-15 adjuvant | 18000037 (2007) |
4 | DNA vaccine expressing multiple HIV epitopes | rev, nef, tat, gag, env, pol | HIV-1 | Auxo-GTU vector system | DNA vaccine alone | 16359234 (2005) |
5 | HIV DNA vaccine pHIS-SHIV-B | env, gag, pol, tat, rev, vpu | SHIV(mn229) | pHIS-64 | DNA vaccine alone | 15564490 (2004) |
6 | HIV DNA vaccine pCMN160 | env, rev, gag-pol | HIV-1 SF2 | pCMN160 | DNA vaccine alone | 9142121 (1997) |
DNA vaccine priming and other vaccine boosting | ||||||
7 | HIV DNA vaccine SIVmac239 Gag-Pol-Nef and mock Env with rAd5 boost | gag, pol, nef, env | SHIV89.6P | pVR1012 | DNA vaccine prime, adenovirus boost | 15613305 (2005) |
8 | HIV DNA and adenoviral vector Ad5 expressing SIV gag protein | gag | SHIV 89.6P16 | pV1R | DNA prime, adenovirus boost | 11797011 (2002) |
9 | HIV DNA vaccine SHIV-89.6 DNA (DNA/89.6) | gag, pol, env, tat, rev, vif, vpr, vpu | SHIV-89.6P | pGA | DNA vaccine with GM-CSF adjuvant prime, MVA boost | 16740288 (2006) |
10 | DNA and poxvirus priming-boosting SHIV vaccine | env, gag | SHIV-89.6P | pV1R | DNA prime with IL-2/Ig adjuvant, poxvirus boost | 15258286 (2004) |
11 | HIV priming with DNA vaccine expressing HIV gp160 protein and boosted with Ad5/35 vector | env, rev | HIV-1 | pCAGGS | DNA prime, adenovirus boost | 16079886 (2005) |
12 | SHIV DNA vaccine encoding env and gag | env (4 from 3 clades*), gag | SHIV-Ba-L | pSW3891 | DNA vaccine prime, protein boost | 16460776 (2006) |
13 | SHIV(Ba-L) DNA vaccine encoding env and gag | env (5 from 4 clades), gag | SHIV-Ba-L | pSW3891 | DNA vaccine prime, protein boost | 16128917 (2005) |
14 | SIV DNA vaccine pVacc4 encoding env from mac239 | env | SHIV89.6P | pVacc4 | DNA vaccine with IL-2/Ig adjuvant prime, MVA boost | 15004179 (2004) |