Figure 3

Comparison of quality score distributions for real and simulated WGS datasets. Top: Ion Torrent. Middle: 454. Bottom: Illumina. 454sim and MetaSim are excluded from the Ion Torrent and Illumina plots, as MetaSim does not generate quality scores and 454sim generated reads with a median quality score of 40 for all positions. GemSIM, 454sim, and SimSeq are unable to match the read length distribution of the 454 data, and as a result their quality score traces end prior to position 860.