Figure 4

Comparison of the location of conserved motif residues in the 3D structures of IGF-1R L1 domain and other LRR and β-helix proteins. The 3D structures are a human, IG1R fragment (PDB: 1IGR, residues 50–143), b, internalin 1B from Listeria monocytogenes (PDB: 1D0B, residues 143–241),c, porcine ribonuclease inhibitor (PDB:2BNH, residues 24–148) and d, pectate lyase C from Erwinia chrysanthemi (PDB:1PEC, residues 86–245). Residues equivalent to conserved positions 1 to 8 in the sequence motif LxxLxLxxNxLxxLxxLxxLxx are colour coded as follows: position 1: blue; positions 2 & 3: green; position 4: yellow; positions 5 – 8: red.