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Table 1 Frequency of occurrence of amino acid residues in the eight conserved positions of the LRR-like motifs in the L domains of the IR and EGFR families

From: The relationship between the L1 and L2 domains of the insulin and epidermal growth factor receptors and leucine-rich repeat modules

Residue

IR Family (L1 + L2)

EGFR Family (L1 + L2)

 

1st

2nd

3rd

4th

5th

6th

7th

8th

1st

2nd

3rd

4th

5th

6th

7th

8th

H

-

1

-

-

-

-

1

-

-

-

2

-

-

1

-

-

K

2

7

-

-

-

-

-

-

-

-

1

2

-

-

-

-

R

-

-

-

-

-

1

-

-

-

-

2

-

3

1

-

-

D

-

-

-

-

1

1

-

-

-

-

-

1

1

-

-

-

E

-

-

-

-

-

-

1

-

-

1

-

-

-

-

-

-

N

-

9

-

68

-

-

2

-

-

-

-

61

-

-

-

-

Q

-

-

1

-

-

2

-

-

1

2

3

3

2

2

-

-

S

-

1

-

12

-

-

-

-

-

-

1

4

-

-

-

-

T

7

-

-

3

-

1

1

-

-

5

2

4

-

-

-

1

P

1

-

-

-

1

-

-

-

-

-

-

-

-

-

-

-

G

1

2

-

-

-

-

-

-

-

-

2

4

-

-

-

-

A

-

1

3

-

1

13

-

-

-

4

2

5

4

5

-

-

V

17

20

26

12

13

4

2

13

35

35

24

6

15

13

6

10

I

91

16

95

5

10

20

13

12

57

18

78

3

14

19

16

9

L

6

70

15

2

85

80

51

64

6

70

13

3

57

69

46

53

M

1

9

2

14

3

-

9

1

-

5

5

1

7

5

13

-

C

26

-

-

-

-

-

 

26

24

1

-

2

-

-

-

24

F

2

7

13

1

11

4

39

-

10

1

8

-

8

4

28

-

Y

1

-

1

-

5

4

 

1

1

2

1

-

6

1

11

-

W

1

-

-

-

-

-

 

13

-

-

-

8

1

-

 

23

  1. Calculated from conserved positions indicated in Figs 2 &3.