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Figure 2 | BMC Bioinformatics

Figure 2

From: RNA:(guanine-N2) methyltransferases RsmC/RsmD and their homologs revisited – bioinformatic analysis and prediction of the active site based on the uncharacterized Mj0882 protein structure

Figure 2

Comparison of the conformations of the "catalytic loop" (motif IV) of N-MTases in stereoview. DNA:m6A MTases: M.Taq I (1g38 in PDB) [29] in yellow, M.Rsr I (leg2) [55] in red, M.Dpn M (2dpm) [56] in green; RNA:m6A MTase ErmC' (1qao) [24] in blue; DNA:m4C MTase M.Pvu II (1boo) [57] in cyan; Mj0882 (1dus) in magenta. The ligand for each protein is shown: AdoMet for M.Dpn M and ErmC', S-adenosylhomocysteine for M.Pvu II, 5'-methylthioadenosine for M.Rsr I, and 5'-[2-(amino)ethylthio]-5'-deoxyadenosine (cofactor analog) and the target deoxyadenosine for M.Taq I. In case of M.Rsr I, ErmC' and M.Pvu II, whose structures were solved in the absence of the target, the Tyr or Phe sidechain can be easily rotated to the M.TaqI-like orientation to make a face-to-face π-stacking interaction with the target base.

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BMC Bioinformatics

ISSN: 1471-2105

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