Table 1 Minimum inhibitory concentration (MIC) of rifampin and associated variable amino acids in positions 511–533 of the β subunit of RNA polymerase of Mycobacterium tuberculosis [2–4].
MIC (μg/ml) | No. of Isolates | No. of Isolates with Differences | Amino Acid Differences from Consensus (No. of Isolates) |
|---|---|---|---|
0.0625 | 48 | 1 | 515:V(1) |
0.125 | 2 | 0 | |
0.25 | 2 | 0 | |
< 0.39 | 13 | 2 | 521:P(1), 533:P(1) |
0.5 | 2 | 1 | 533:P(1) |
1 | 3 | 1 | 533:P(1) |
2 | 2 | 1 | 511:R and 512:T(1) |
4 | 2 | 1 | 516:V(1) |
8 | 6 | 5 | 516:V(1), 526:G(1), 526:L(2), 526:Q and 533:P(1) |
12.5 | 3 | 3 | 514:L and 516:V(1), 533:P(2) |
16 | 3 | 3 | 526:L(1), 526:N(1), 529:K(1) |
32 | 1 | 0 | |
> 32 | 15 | 15 | 511:R and 516:Y(1), 513:K(1), 513:L(1), 526:D(2), 526:Y(4), 531:L(4), 531:W(1), 533:P(1) |
50 | 1 | 1 | 531:L(1) |
64 | 7 | 7 | 531:L(7) |
100 | 1 | 1 | 531:L(1) |
128 | 19 | 19 | 513:L(1), 516:Y(1), 526Y(1), 531L(16) |
200 | 1 | 1 | 526:D(1) |
> 200 | 7 | 7 | 513:L(1), 516:A and 526:D(1), 526:P(1), 526:Y(2), 531:L(2) |
256 | 13 | 13 | 513:K(1), 516:Y and 526:N(1), 526:P(1), 531:L(10) |
512 | 18 | 18 | 526:P(4), 526:R(2), 526:Y(3), 531:L(7), 531:W(2) |
> 512 | 4 | 4 | 516:Y(1), 526:D(1), 526:P(1), 531:W(1) |