Extending the mutual information measure to rank inferred literature relationships

BMC Bioinformatics

Table 3 Swanson's implicit discoveries analyzed either by counting the number of shared relationships or by the MMIM score. Frequency (Freq) is the number of co-mentions the two objects share in the literature. Notice that the type of relationship that ranks higher with the MMIM tends to be more specific and informative, while the terms that share the most relationships tend to be more general and vague.

Ranked by # of shared relationships					Ranked by Minimum MIM
Query term (A)	Implicit relationship (C)	Shared rels	MMIM Score	Freq.	Implicit relationship (C)	Shared rels	MMIM Score	Freq.
migraine	Migraine	1442	4149	-	migraine	1442	4149	-
migraine	development	1362	216	348	Headache	1140	1519	4032
migraine	Lesions	1291	264	164	Sumatriptan	270	1038	1152
migraine	nervous system	1280	311	227	Nausea	899	886	323
migraine	pathogenesis	1253	375	475	Vomiting	889	732	242
migraine	Muscle	1251	201	184	Dizziness	696	669	136
migraine	Blood	1236	63	272	Ataxia	674	562	62
migraine	Tumor	1236	93	158	Vertigo	467	511	208
migraine	Females	1223	243	200	Somnolence	389	497	19
migraine	Males	1219	238	169	Seizures	1057	493	198
Query term (A)	Implicit relationship (C)	Shared rels	MMIM Score	Freq.	Implicit relationship (C)	Shared rels	MMIM Score	Freq.
Raynaud's	Raynaud's syndrome	200	2088	-	Raynaud's syndrome	200	2088	-
Raynaud's	development	198	45	11	Raynaud's phenomenon	183	1204	45
Raynaud's	Artery	195	86	36	Raynaud's disease	118	936	30
Raynaud's	Muscle	193	53	2	mixed connective tissue disease	121	870	13
Raynaud's	pathogenesis	192	127	18	Scleroderma	161	862	48
Raynaud's	Lesions	192	71	26	connective tissue diseases	151	842	31
Raynaud's	Vessels	191	108	10	Arthralgia	133	761	6
Raynaud's	Blood	190	16	26	overlap syndrome	81	619	1
Raynaud's	Skin	190	24	18	Calcinosis	104	592	7
Raynaud's	Cutaneous	189	200	13	progressive systemic sclerosis	124	587	14

ISSN: 1471-2105