From: Network analysis of metabolic enzyme evolution in Escherichia coli
 | WHOLE NETWORK | REDUCED NETWORK | ||
---|---|---|---|---|
RANK | ENZYME | K | ENZYME | K |
1 | Carbamoyl phosphate synthase | 735 | Taurine dioxygenase | 61 |
2 | ATP synthase | 704 | Aspartate transaminase | 57 |
3 | Phosphoenolpyruvate synthase | 604 | Isocitrate dehydrogenase | 56 |
4 | S-adenosylmethionine synthetase I | 603 | Malate oxidase | 53 |
5 | NAD+ synthase | 599 | Quinolinate synthetase | 48 |
6 | NADP phosphatase | 583 | Alpha-galactosidase | 46 |
7 | Asparagine synthase B | 578 | 3-dimethylubiquinone 3-methyltransferase | 46 |
8 | Selenophosphate synthase | 563 | Transketolase I | 45 |
9 | Methionine adenosyltransferase 2 | 558 | Fructose 1,6-bisphosphatase II | 45 |
10 | Mg2+-importing ATPase | 558 | Glutamate synthase (NADPH) | 45 |