Figure 1

Interface residues predictions mapped on the three dimensional structure of Proteinase B from Streptomyces griseus (3sgb). The target protein is shown in ribbons and atomic spheres; the inhibitor partner is shown at the top in faint wire frame. The residues are color coded as: red = true positives (TP), gray = true negatives (TN), yellow = false negatives (FN), and blue = false positives (FP). Red, yellow, and blue residues are shown in spacefill representation. Note that the actual interface residues extracted from the PDB structure include the red (TP) and yellow (FN) residues. Red and gray residues represent correct predictions of interface and non-interface residues (14 TP+ 210 TN = 224 correct predictions); yellow and blue residues represent incorrect predictions (1 FN + 2 FP= 3)