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Table 1 Convergence of type I error rates of the MRT test based on chi-squared approximation. The type I error rates of the MRT test based on chi-squared approximation were evaluated under varying sample sizes. A 2 × 2 design and a 3 × 4 design were considered.

From: Nonparametric tests for differential gene expression and interaction effects in multi-factorial microarray experiments

Dist

Design

N = 5

N = 15

N = 20

N

2 × 2

0.077

0.047

0.052

 

3 × 4

0.075

0.055

0.053

U

2 × 2

0.075

0.046

0.051

 

3 × 4

0.083

0.055

0.053

LN

2 × 2

0.074

0.060

0.055

 

3 × 4

0.078

0.061

0.056

CN

2 × 2

0.081

0.053

0.051

 

3 × 4

0.072

0.054

0.053

C

2 × 2

0.072

0.046

0.052

 

3 × 4

0.068

0.061

0.055