Figure 4
The gene expression phases match the main regulatory functions of TFs. It is seen that the main interaction functions of TFs have a peak value and always occur during or soon after the mRNA expression phases of the corresponding genes. For example, the gene MFA2 has the main interaction regulatory function gMcm1,Swi5(t) which has a peak during the expression phases between the TFs Mcm1 and Swi5 by identifying the cis-regulatory circuit. As another example, the gene UTR2 has the main interaction regulatory function gSwi 4,Swi 6(t), which has a peak during the expression phases between the TFs Swi4 and Swi6 by identifying the cis-regulatory circuit. These results indicate that the main regulatory functions have a peak value phase to match the gene expression phase. Therefore, we can estimate the gene expression phase by identifying the main regulatory function. The width of a colored band in the inner circle is approximately proportional to the expression level of the TF gene of interest in the cell cycle. A pink line points to the main expression phase of a target gene in the pink box. Different phases in the cell cycle are indicated by the colored bar at the right lower corner.