Figure 1

Bar plots show comparison of RMSEs by using the global method (black bar), the lowess method (grey bar), and the adaptive method (white bar) for normalization with simulated data generated from a mixture model with c = 1.5, a = 118, a₀ = 410, γ = 31, γ₁ = 23, and γ₂ = 29 at three different noise levels (A) SD = 0; (B) SD = 0.25; and (C) SD = 0.50.