Figure 3

Examples of topology in the CI space. In 4 cases where there is a strong cross similarity between sequences belonging to two different EC classes, we plot for each protein of these classes a point whose 2 coordinates are the CIs of its sequence with the two functional classes (BLAST best-hit with the corresponding EC class). (a): EC 2.3.1.61 (black circles) and EC 2.3.1.12 (grey triangles); crosses on top and at right correspond to the projection on the CI axes; the dotted circle (boxes on top and to the right) marks the limit of the sampling regions used to annotate O31550 with the multivariate (univariate) Bayesian method [See Additional file 1, Fig. S1]. (b): EC 1.6.5.3 (black triangles) and EC 1.6.99.5 (grey circles). (c): EC 1.2.1.59 (black triangles) and EC 1.2.1.12 (grey circles). (d): EC 1.4.1.3 (black triangles) and EC 1.4.1.4 (grey circles); the arrow shows the change of position of protein P94598 in the CI space when the annotation of P95544 is corrected from EC 1.4.1.4 to EC 1.4.1.3 (See Analysing the origins of annotation errors).