Figure 2

Demonstration of reproducibility of the SELDI experiments in liver cancer and liver toxicity study. The reproducibility of SELDI experiments was measured by the consistency of expression levels (peak intensities in spectra) of the five common proteins appearing in all 144 quality control samples used in the liver cancer and liver toxicity study. The numbers on the x-axes are the m/z values of peaks (in KDa.). (A) The average intensities of the five peaks in the 144 spectra are represented by the blue cylinders and the corresponding standard deviations depicting the variations in the 144 spectra are shown in red cylinders. (B) The coefficient of variation (CV), which is used to measure the precision of the peak intensity common in the 144 spectra from the set of SELDI experiments, is depicted as blue cylinders. All CVs are less than 0.2, which is considered acceptable reproducibility in SELDI.