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Figure 8 | BMC Bioinformatics

Figure 8

From: Detecting outliers when fitting data with nonlinear regression – a new method based on robust nonlinear regression and the false discovery rate

Figure 8

The ROUT method is not fooled by totally random data. These data were simulated from a Gaussian distribution around a horizontal line. Each simulated data set was then fit to a sigmoid dose-response curve, fixing the bottom plateau and slope, and fitting the top plateau and the EC50. Our fear was that our method would define many points to 'outliers' and leave behind points that define a dose-response curve. That didn't happen. Our method found an outlier in only one of 1000 simulations.

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BMC Bioinformatics

ISSN: 1471-2105

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