Table 3 Differentially expressed genes common to two independent transcript profiling studies of human breast tissue [26,32]. The table shows LUMINAL and MYOEPITHELIAL genes [26] that were identified also by a SAGE study [32]; the column labelled "Cluster" indicates the "Consensus cluster" to which the gene was assigned (taken from Table 1 or Table 2). †denotes genes present in genomic regions found to be altered in a CGH study of invasive ductal breast carcinomas [33].
LUMINAL | ||
|---|---|---|
Cluster | Location | Symbol (LocusID): description |
0 | 6q21 | CD24 (934): CD24 antigen, small cell lung carcinoma cluster 4 antigen |
|  | †7q11.23 | CLDN4 (1364): claudin 4 |
| Â | 12q13 | ERBB3 (2065): v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) |
|  | †17q25.2 | SLC9A3R1 (9368): solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1 |
|  | †19pl3.3 | GADD45B (4616): growth arrest and DNA-damage-inducible, β |
1 | 14q32 | TNFAIP2 (7127): tumor necrosis factor, α-induced protein 2 |
2 | 14q22-q24 | ZFP36L1 (677): zinc finger protein 36, C3H type-like 1 |
MYOEPITHELIAL | ||
Cluster | Location | Symbol (LocusID): description |
0 | 2p25 | ID2 (3398): inhibitor of DNA binding 2, dominant negative helix- loop- helix protein |
| Â | 5q31.3-q32 | SPARC (6678): secreted protein, acidic, cysteine-rich, osteonectin |
| Â | 12p13 | GAPD (2597): glyceraldehyde-3-phosphate dehydrogenase |
|  | †17q21.3-q22.1 | COL1A1 (1277): collagen, type I, α 1 |
1 | 1q22-q25 | SELE (6401): selectin E, endothelial adhesion molecule 1 |
|  | †4q13-q21 | AREG (374): amphiregulin, schwannoma- derived growth factor |
2 | 1p35.3 | SFN (2810): stratifin |
|  | †10q26.3 | PRSS11 (5654): protease, serine, 11 [IGF binding] |
3 | 2p21-p16 | EPAS1 (2034): endothelial PAS domain protein 1 |
| Â | 3q27-q29 | TP73L (8626): tumor protein p73-like |