Table 2 Performance of proteochemometric models. Performance of proteochemometric models derived using wild-type and multiple chimeric receptors interacting with melanocortins, α-MSH, NDP-MSH and [125]-NDP-MSH. Shown are results from the model based on binary receptor descriptors (A) and the model based on physicochemical description of amino acids of the transmembrane regions presumed to face in a direction opposite to the membrane (B) (see Methods for further details).