Figure 4

Correlation of p53 protein isoforms towards AML differentiation (FAB). Green indicates correlation with more differentiated forms of AML. Such areas in 2DE images of M5 will have a higher intensity than 2DE images of M0. Brown indicates anti-correlation with the more mature forms of leukemia cells. Such areas in 2DE images of M0 will have a higher intensity than 2DE images of M5. (A) Correlation landscape of p53 in 73 AML images related to differentiation direction and stage (FAB, French-American-British classification). The vertical axis sets out the absolute correlation value. (B) Correlation image demonstrating statistical significant alterations in p53. Profile 1 shows the p53-δ region containing four correlating spots (r = 0.2). Profile 2 shows the sub-δ region anti-correlating at positions e and f. Profile 3 is the p63 region (p53 family member) correlating towards the more differentiated leukemia's. Profile 4, a p53 region anti-correlating with differentiated AML.