| Sets of confused folds, S | Number of domains in S | Sheba FPR S (%) | Sheba TPR S (%) | Sheba FPRS/TPRS(%) | Vast FPR S (%) | Vast TPR S (%) | Vast FPRS/TPRS(%) | Explanation for confusion |
---|---|---|---|---|---|---|---|---|---|
1 | a.28, a.39 | 50 | 29 | 57 | 51 | 10 | 16 | 64 | 4 helix bundle up-and-down (a.28), and 4 helix array of 2 hairpins folds. Confusion is caused by match of helices oriented similarly. Folds confused mostly by SHEBA. |
2 | a.46, a.52 | 9 | 45 | 97 | 46 | 7 | 36 | 20 | 4 helix bundle left and right-handed super helix (a.46), and 4 helix right-handed super helix folds. Confusion is caused by match of helices oriented similarly. Folds confused mostly by SHEBA. |
3 | a.47, a.7 | 24 | 87 | 88 | 98 | 8 | 20 | 40 | 3 helix bundle (a.7) and 4 helix bundle (a.47) folds. Confusion due to match of very similar structure. Folds confused mostly by SHEBA. |
4 | b.68, b.69, b.66, b.67, b.70 | 45 | 92 | 98 | 94 | 40 | 83 | 48 | Beta-propellers (repetitive 4-stranded blades) folds, of 4, 5, 6, 7 or 8 blades depending on the fold. Confusion is caused by match of several 4-stranded blades among domains of these folds. |
5 | b.1, b.2, b.3, b.7, b.12. | 297 | 19 | 66 | 29 | 32 | 68 | 48 | Beta sandwich folds of 7, 8, 9 stranded-sheet, with Greek-key topology. The motif causing the confusion among folds is a sandwich, which is rather well matched between domains of these folds. |
6 | b.24, b.71 | 24 | 69 | 97 | 72 | 27 | 93 | 29 | Sandwich fold, with 10 strands in 2 sheets, and "folded meander topology" fold (b.24), and folded sheet with Greek-key topology. Confusion is due to match of parts of the sheets of the common core of these folds. |
7 | b.60, b.61 | 30 | 63 | 90 | 70 | 57 | 78 | 74 | Closed barrel, with meander topology. Confusion caused by good match of between barrel motifs of the common core. |
8 | b.43, b.49, b.58, b.44 | 39 | 42 | 71 | 59 | 32 | 72 | 44 | Folds of closed barrel with Greek-key topology. Confusion is due the match of substantial part of the barrel common core, among domains of these folds. |
9 | b.107, b.4 | 4 | 100 | 100 | 100 | 25 | 100 | 25 | Sandwich fold (b.4), and closed barrel fold (b.107). Confusion is caused by the good match between a deformed barrel motif and a sandwich motif. |
10 | b.34, b.38 | 62 | 69 | 67 | 103 | 19 | 49 | 39 | Barrel folds, with meander topology. Confusion is caused by the match between the barrel common cores. |
11 | b.38, b.56 | 12 | 52 | 100 | 52 | 65 | 93 | 70 | Open barrel (b.38) and closed barrel (b.56) folds. Confusion is caused by the match of the barrel. |
12 | b.10, b.19, b.13, b.18, b.22, b.23 | 91 | 42 | 76 | 55 | 16 | 54 | 29 | Folds with common core motif of beta sandwich; the 2 sheets are made of 8, 9 or 10 strands depending on the fold, and with jelly roll topology. The confusion among these folds is caused by the match of the strands of the beta sandwich common core. |
13 | c.1, c.6 | 185 | 62 | 75 | 83 | 78 | 87 | 90 | TIM barrel (c.1) and variant of beta/alpha barrel, with closed parallel beta-sheet barrel (c.6) folds. Confusion is caused by the match of almost the whole TIM barrel. |
14 | c.8, c.98 | 14 | 50 | 75 | 68 | 30 | 54 | 56 | 3 layer beta/beta/alpha (c.8) and 3 layer alpha/beta/alpha (c.98) folds. Confusion is caused by the match between common beta/alpha layers. |
15 | c.84, c.95 | 19 | 65 | 91 | 71 | 55 | 92 | 60 | 3 layer alpha/beta/alpha of 4 strands (c.84), and of 5 strands (c.95) folds. Match of the 3 layer alpha/beta/alpha common core causes the confusion. |
16 | c.101, c.73, c.27 | 7 | 11 | 100 | 11 | 49 | 100 | 49 | 3 layer alpha/beta/alpha folds, with 5, 6 or 8 strands depending on the fold. Confusion is caused by the match of the 3 layer alpha/beta/alpha common core. |
17 | c.100, c.28, c.25, c.24, c.30, c.78, c.108, c.116, c.31, c.114, c.3, c.4, c.49, c.59, c.16, c.57, c.44, c.48, c.2, c.33, c.32, c.34, c.23, c.62, c.65, c.5 | 334 | 24 | 80 | 31 | 51 | 92 | 56 | 3 layer alpha/beta/alpha folds, with beta sheet of 4, 5, 6 or 7 strands depending of the fold. 3 layer beta/beta/alpha with central of 5 strands for c.3. Confusion among 3 layer alpha/beta/alpha folds is caused by the match of the 3 layer alpha/beta/alpha common core. Confusion between 3 layer alpha/beta/alpha and beta/beta/alpha is caused by the match of the 2 layer beta/alpha. |
18 | d.13, d.173 | 7 | 26 | 93 | 28 | 43 | 86 | 50 | Fold containing the 3 layer alpha/beta/alpha common core (d.130 and unusual fold containing a common core of beta-alpha-beta-alpha-beta-alpha-beta (d.173). Confusion caused by the match of some strands and helices. |
19 | d.65, d.67 | 7 | 47 | 46 | 102 | 60 | 64 | 93 | 2 layer alpha/beta sandwich fold. Confusion caused by the match of 2 layer alpha/beta sandwich common core. |
20 | d.181, d.212 | 5 | 50 | 60 | 83 | 17 | 60 | 28 | Folds containing beta-alpha-beta units. Confusion caused by match on the alpha/beta layers. |
21 | d.10, d.50 | 14 | 34 | 66 | 51 | 40 | 61 | 66 | 2 layer alpha/beta folds. Confusion caused by match on the 2 layer alpha/beta common cores. |
22 | d.140, d.68 | 12 | 34 | 68 | 51 | 40 | 52 | 77 | Fold with 2 layer beta/alpha sandwich common core. Confusion is caused by match of the 2 layer beta/alpha sandwich. |
23 | d.151, d.160 | 7 | 75 | 100 | 75 | 58 | 100 | 58 | Beta-sandwich; duplication of alpha+beta (d.151), 4 layers: alpha/beta/beta/alpha; mixed beta sheets (d.160) folds. Confusion due to match of the alpha beta sandwich. |
24 | d.95, d.206, d.64 | 12 | 18 | 96 | 18 | 34 | 79 | 43 | 2 layer alpha/beta sandwich folds. Confusion caused by the match of the 2 layer alpha/beta sandwich. |
25 | d.11, d.40 | 5 | 100 | 100 | 100 | 67 | 100 | 67 | 2 layer alpha/beta sandwich folds. Confusion caused by match of the 2 layer alpha/beta sandwich. |
26 | d.130, d.80, d.52 | 19 | 53 | 90 | 59 | 51 | 62 | 82 | 2 layer alpha/beta sandwich folds. Confusion is caused by the match of the 2 layer alpha/beta sandwich. |
27 | d.45, d.74, d.58, d.51, d.94, d.141, d.105 | 160 | 43 | 58 | 74 | 48 | 59 | 81 | 2 layer alpha/beta sandwich, and two beta-sheets and one alpha-helix packed around single core (d.141) folds. Confusion caused by match of the sheet and strands of the 2 layer alpha/beta sandwich core motif. |
28 | e.24, c.16, c.57, c.44, c.23, c.5 | 79 | 47 | 73 | 64 | 68 | 85 | 80 | A domain component of a "multi-domain" domain of fold e.24 can matches the full domain of another fold which does not belong to the E class |
29 | e.4, c.48, c.2, c.32, c.33, c.34, c.23 | 178 | 35 | 74 | 48 | 74 | 87 | 85 | A domain component of a "multi-domain" domain of fold e.4 matches the full domain of another fold which does not belong to the E class |