Table 8 Comparison to other protein disorder predictors over a blind-test set. The non-redundant blind-test set contained 1,304 recent PDB chains that were unrelated to any VSL2 training sequence. The three VSL2 predictors were re-trained with all 1,327 training sequences. The prediction accuracies were calculated at default thresholds, e.g. 0.5 for VL-XT, VL3-E, VSL1, VSL2B, VSL2P and VSL2.
From: Length-dependent prediction of protein intrinsic disorder
| Â | SN | SP | ACC | SN S | SN L | AUC |
|---|---|---|---|---|---|---|
VL-XT | 56.0 | 77.9 | 67.0 | 55.8 | 53.0 | 74.4 |
VL3-E | 28.4 | 91.4 | 59.9 | 26.8 | 59.7 | 69.2 |
DisEMBL | 25.9 | 97.9 | 61.9 | 25.7 | 26.5 | 83.9 |
RONN | 34.7 | 88.8 | 61.8 | 33.6 | 56.4 | 67.2 |
DISOPRED2 | 53.8 | 94.7 | 74.2 | 53.5 | 48.6 | 84.6 |
VSL1 | 75.6 | 85.8 | 80.7 | 76.1 | 63.6 | 88.5 |
VSL2B | 73.7 | 80.8 | 77.3 | 74.2 | 63.1 | 84.1 |
VSL2P | 78.4 | 80.4 | 79.4 | 78.5 | 71.6 | 86.7 |
VSL2 | 79.4 | 81.4 | 80.4 | 79.6 | 73.7 | 87.5 |
(a) per-chain | ||||||
| Â | SN | SP | ACC | SN S | SN L | AUC |
VL-XT | 54.2 | 79.2 | 66.7 | 54.7 | 52.3 | 74.0 |
VL3-E | 36.5 | 93.9 | 65.2 | 30.5 | 59.2 | 75.9 |
DisEMBL | 25.3 | 98.3 | 61.8 | 25.4 | 24.7 | 80.1 |
RONN | 41.6 | 89.1 | 65.4 | 39.1 | 51.2 | 71.3 |
DISOPRED2 | 47.8 | 95.6 | 71.7 | 48.7 | 44.6 | 83.4 |
VSL1 | 68.3 | 87.4 | 77.9 | 70.9 | 58.3 | 86.2 |
VSL2B | 67.1 | 82.6 | 74.8 | 68.9 | 60.3 | 82.0 |
VSL2P | 72.7 | 82.5 | 77.6 | 74.2 | 67.1 | 85.3 |
VSL2 | 74.7 | 82.8 | 78.7 | 76.1 | 69.4 | 86.3 |
(b) per-residue | ||||||