Table 5 Kinetic parameters for dynamic simulation
Affinity of domain | k on [M-1min-1] | k off [min-1] | Equilibrium K d [M-1] |
|---|---|---|---|
1 (always) | k1 = 3·105 | k-1 = 6 | 5·104 |
2 (domain 1 unoccupied) | k2 = 1 | k-2 = 18 | 5.6·10-2 |
2 (domain 1 occupied) | k3 = 5·107 | k-3 = 24 | 2.1·106 |
3 (domain 1 unoccupied) | k4 = 1 | k-4 = 12 | 8.3·10-2 |
3 (domain 1 occupied) | k5 = 1·105 | k-5 = 60 | 1.7·103 |