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Table 2 Significant TFBS of PTM subclusters from the AML data set.

From: Analysis of promoter regions of co-expressed genes identified by microarray analysis

Cluster1

Subclusters

Number of genes

Significant TFBS present in all promoters of a givencluster2

FOXO3A

1A

3

No significant TFBS

 

1B

6

CAAT, CETS1P54, FOXO4 (FOXO1 (4/6) FOXO3 (4/6))

 

1C

4

No significant TFBS

MAX

2A

12

Significant TFBS but not present in all

 

2B

13

AP1, BARBIE, GATA, GATA1, HFH3, LMO2COM

SP3

3A

6

Significant TFBS but not present in all

 

3B

8

No significant TFBS

 

3C

5

Significant TFBS but not present in all

 

3D

13

AP1, BARBIE, CAAT, CEBPDELTA, CETS1P54, FOXO4, GATA, GATA1, LMO2COM, NKX25, S8

STAT3

4A

6

MAZ, NRF2

 

4B

6

AP1, GATA, GATA1, LIMO2COM

TGIF2

5A

7

Significant TFBS but not present in all

 

5B

4

CETS136, ELK1, ETS1, FOXO4, GATA, GATA1, IK1, LMO2COM, NRF2, RFX1, SREBP1, TGIF, USF

  1. 1 DNA binding transcription factor used for cluster formation.
  2. 2 Significant TFBS present in all promoters of the subcluster genes and the TFBS in parenthesis are present in the fraction promoters indicated.