Table 3 45 genes up-regulated in tumoral tissue, comparing normal mucosa to matched tumor colon tissue.
From: On the statistical assessment of classifiers using DNA microarray data
Function | Gene | OMIM | Accession no. | p-value | Gene description |
|---|---|---|---|---|---|
Cell cycle: mitosis (spindle checkpoint) | TTK | 604092 | NM_003318.1 | 0.029 | Threonine-tyrosine kinase |
| Â | BUB1 | 602452 | AF043294.2 | 0.035 | Budding uninhibited by benzimidazoles 1 homolog (yeast) |
| Â | BUB3 | 603719 | NM_004725.1 | 0.037 | Budding uninhibited by benzimidazoles 3 homolog (yeast) |
| Â | CDC20 | 603618 | NM_001255.1 | 0.044 | Cell division cycle 20 |
| Â | MAD2L1 | 602686 | NM_002358.2 | 0.049 | MAD2 (mitotic arrest deficient, yeast, homolog) like-1 |
| Â | BUB1B | 602860 | NM_001211.2 | 0.050 | Budding uninhibited by benzimidazoles 1 homolog beta (yeast) |
Cell cycle: G0/G1 transition | INSIG1 | 602055 | NM_005542.1 | 0.039 | Insulin induced gene 1 (cell division cycle, G0 to G1) |
Cell cycle: mitosis (G1/S checkpoint) | CKS2 | 116901 | NM_001827.1 | 0.047 | CDC28 protein kinase regulatory subunit 2 |
| Â | CKS1B | 116900 | NM_001826.1 | 0.046 | CDC28 protein kinase regulatory subunit 1B |
| Â | SKP2 | 601436 | BG105365 | 0.050 | S-phase kinase-associated protein 2 (p45) |
| Â | FOXM1 | 602341 | NM_021953.1 | 0.045 | Forkhead box M1 |
| Â | MCM4 | 602638 | AA 604621 | 0.036 | Minichromosome maintenance deficient (S. cerevisiae) 4 |
| Â | MCM3 | 602693 | NM_002388.2 | 0.048 | Minichromosome maintenance deficient (S. cerevisiae) 3 |
| Â | MCM7 | 600592 | D55716.1 | 0.048 | Minichromosome maintenance deficient 7 (S. cerevisiae) |
| Â | MCM2 | 116945 | NM_004526.1 | 0.049 | Minichromosome maintenance deficient (S. cerevisiae) 2 |
| Â | MCM6 | 601806 | NM_005915.2 | 0.050 | Minichromosome maintenance deficient (S. pombe) 6 |
Cell cycle: mitosis (G1/S and G2/M checkpoints) | CRKRS | Â | M68520.1 | 0.039 | Cdc2-related kinase, arginine/serine-rich |
| Â | CDC2/CDK1 | 116940 | NM_001786.1 | 0.044 | Cell division cycle 2, G1 to S and G2 to M |
| Â | CDC25A | 116947 | NM_001789.1 | 0.050 | Cell division cycle 25A |
| Â | CDC25B | 116949 | NM_021873.1 | 0.050 | Cell division cycle 25B |
| Â | CCNA2 | 123835 | NM_001237.1 | 0.050 | Cyclin A2 |
Cell cycle: mitosis (G2/M checkpoint) | CCNB1 | 123836 | Hs.23960 | 0.047 | Cyclin B1(cell division cycle, G2 to M) |
| Â | CCNB2 | 602755 | NM_004701.2 | 0.047 | Cyclin B2 (cell division cycle, G2 to M) |
| Â | NEK2 | 604043 | NM_002497.1 | 0.037 | NIMA (never in mitosis gene a)-related kinase 2 |
Cell cycle: mitosis | STK15 | 602687 | NM_003600.1 | 0.039 | Serine/threonine kinase 6 (chr segregation) |
| Â | SRPK1 | 601939 | NM_003137.1 | 0.046 | SFRS protein kinase 1 (chr segregation) |
| Â | TOP2A | 126430 | NM_001067.1 | 0.050 | Topoisomerase (DNA) II alpha (170 kD) (chr segregation) |
| Â | KIF4A | 300521 | NM_012310.2 | 0.035 | Kinesin family member 4A (spindle formation/chr condensation) |
| Â | CNAP1 | 609689 | NM.014865 | 0.046 | Chromosome condensation-related SMC-associated protein 1 |
| Â | SMC4L1 | Â | NM_005496.1 | 0.048 | SMC4 structural maintenance of chromosomes 4-like 1 (yeast) |
| Â | HCAP-G | 606280 | NM_022346.1 | 0.042 | Chromosome condensation protein G (chr condensation) |
Signal transduction | TDGF1 | 187395 | NM_003212.1 | 0.048 | Teratocarcinoma-derived growth factor 1 (EGF signaling) |
| Â | ENC1 | 605173 | NM_003633.1 | 0.048 | Pig 10, ectodermal-neural cortex (WNT//beta-catenin pathway) |
Transcription | SOX9 | 608160 | NM_000346.1 | 0.045 | Sex determining region Y-box 9 |
| Â | MYC | 190080 | NM_002467.1 | 0.047 | V-myc avian myelocytomatosis viral oncogene homolog |
| Â | HGFR/MET | 164860 | NM_002467.1 | 0.047 | Met proto-oncogene |
Transport: intracellular | NUP62 | 605815 | NM_012346.1 | 0.039 | Nucleoporin 62 kD |
| Â | NUPL1 | 607615 | NM_007342.1 | 0.050 | Nucleoporin-like 1 |
| Â | NUP155 | 606694 | NM_004298.1 | 0.045 | Nucleoporin 155 kD (NUP155) |
| Â | KPNA2 | 600685 | NM_002266.1 | 0.045 | Karyopherin alpha 2 (RAG cohort 1, importin alpha 1) |
| Â | RANBP5 | 602008 | NM_002271.1 | 0.050 | RAN binding protein 5 or karyopherin (importin) beta 3 |
| Â | CSE1L/CAS | 601342 | NM_001316 | 0.050 | CSE1 chromosome segregation 1-like (yeast) |
| Â | NXT1 | 605811 | NM_005796.1 | 0.050 | Nuclear transport factor 2 (NTF2) |
| Â | RANBP1 | 601180 | NM_002882.2 | 0.048 | RAN binding protein 1 |
Transport | SLCO4A1 | 605495 | NM_016354.1 | 0.048 | Solute carrier family 21 (organic anion transporter) |