Table 4 47 genes down-regulated in tumoral tissue, comparing normal mucosa to matched tumor colon tissue.
From: On the statistical assessment of classifiers using DNA microarray data
Function | Gene | OMIM | Accession no. | p-value | Gene description |
|---|---|---|---|---|---|
Apoptosis | PDCD4 | 608610 | NM_014456.1 | 0.032 | Programmed cell death 4 (neoplastic transformation inhibitor) |
| Â | FAS | 604306 | NM_000043.1 | 0.044 | Fas (TNF receptor superfamily, member 6) |
| Â | CASP7 | 601761 | NM_001227.1 | 0.050 | Caspase 7, apoptosis-related cysteine protease |
Transport | SLC30A10 | Â | NM_018713.1 | 0.036 | Solute carrier family 30, member 10 (zinc transport?) |
| Â | SLC9A2 | 600530 | AF073299.1 | 0.041 | Solute carrier family 9 (sodium/hydrogen exchanger), member 2 |
| Â | SLC4A4 | 603345 | AF069510.1 | 0.041 | Solute carrier family 4, sodium bicarbonate cotransporter, member 4 |
| Â | SLC26A3 | 126650 | NM_000111.1 | 0.044 | Solute carrier family 26, member 3 |
| Â | SLC26A2 | 606718 | AI025519 | 0.044 | Solute carrier family 26 (sulfate transporter), member 2 |
| Â | SGK2 | 607589 | NM_016276.1 | 0.038 | Serum glucocorticoid regul. kinase 2 (potassium channel activation) |
| Â | KIF5C | 604593 | NM_004522.1 | 0.040 | Kinesin family member 5C (intracellu-lar transport) |
| Â | KIF13B | 607350 | NM_015254.1 | 0.046 | Kinesin family member 13B (intracel-lular transport) |
| Â | VAPA | 605703 | AF154847.1 | 0.047 | VAMP (vesicle-associated membrane protein)-assoc. protein A,33 kDa |
Signalling | MAP2K4 | 601335 | NM_022129.1 | 0.033 | Mitogen-activated protein kinase kinase 4 (MAPK signaling pathway) |
| Â | RPS6KA5 | 603608 | AF074393.1 | 0.040 | Ribos. prot. S6 kinase, 90 kDa, polyp. 5(MAPK signalling pathway) |
| Â | MEF2C | 600662 | L08895.1 | 0.033 | MADS box transcr. enhancer factor 2, (MAPK signalling pathway) |
| Â | PPP2R3A | 604944 | NM_002718.1 | 0.037 | Protein phosphatase 2, regulatory sub-unit B, alpha (Wnt signalling) |
| Â | PDE9A | 602973 | NM_002606.1 | 0.040 | Phosphodiesterase 9A (signal transduc-tion) |
| Â | PPAP2A | 607124 | AF014403.1 | 0.042 | Phosphatidic acid phosphatase type 2A (signal transduction) |
| Â | MUC4 | 158372 | AJ242547.1 | 0.044 | Mucin 4 (Erb2 signalling pathway) |
| Â | DSCR1 | 602917 | AL049369.1 | 0.045 | Down syndrome critical region gene 1 (signal transduction) |
| Â | SHOC2 | 602775 | NM_007373.1 | 0.046 | Soc-2 suppressor of clear homolog (MAPK signaling pathway) |
| Â | SOCS2 | 605117 | NM_003877.1 | 0.049 | Suppressor of cytokine signaling 2 (GH/IGF1 signaling pathway) |
| Â | SMAD2 | 601366 | NM_005901.1 | 0.049 | SMAD, homolog 2 (Drosophila) (TGF-beta_signaling) |
Cell-surface signalling | TSPAN7 | 300096 | NM_004615.1 | 0.036 | Tetraspanin 7 |
| Â | EDG2 | 602282 | NM_001401.1 | 0.041 | Lysophosphatidic acid G-protein-coupled receptor, 2 |
| Â | TMPRSS2 | 602060 | AF270487.1 | 0.046 | Transmembrane protease, serine 2 |
| Â | CEACAM7 | Â | NM_006890.1 | 0.047 | Carcinoembryonic antigen-related cell adhesion molecule 7 |
Cell adhesion | DSC2 | 125645 | NM_004949.1 | 0.045 | Desmocollin 2 |
Cell differentiation | NDRG2 | 605272 | NM_016250.1 | 0.038 | NDRG family member 2 |
| Â | EPB41L3 | 605331 | NM_012307.1 | 0.044 | Erythrocyte membrane protein band 4.1-like 3 (suppressor gene?) |
| Â | MTUS1 | 609589 | NM_024307.1 | 0.045 | Mitochondrial tumor suppressor 1 |
Metabolism | HMGCL | 246450 | NM_000191.1 | 0.040 | 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase |
| Â | UGDH | 603370 | NM_003359.1 | 0.041 | UDP-glucose dehydrogenase |
| Â | CA12 | 603263 | NM_001218.2 | 0.044 | Carbonic anhydrase XII |
| Â | CA2 | 259730 | NM_000067.1 | 0.049 | Carbonic anhydrase II |
| Â | CA4 | 114760 | NM_000717.2 | 0.050 | Carbonic anhydrase IV |
| Â | CA1 | 114800 | NM_001738.1 | 0.050 | Carbonic anhydrase I |
| Â | CA7 | 114770 | NM_005182.1 | 0.050 | Carbonic anhydrase VII |
| Â | HPGD | 601688 | U63296.1 | 0.046 | Hydroxyprostaglandin dehydrogenase 15-(NAD) |
| Â | FUCA1 | 230000 | NM_000147.1 | 0.047 | Fucosidase, alpha-L-1, tissue |
| Â | ACAT1 | 607809 | NM_000019.1 | 0.048 | Acetyl-Coenzyme A acetyltransferase 1 |
| Â | ADH1C | 103730 | NM_000669.2 | 0.048 | Alcohol dehydrogenase3 (class I), gamma polypeptide |
| Â | AQP8 | 603750 | NM_001169.1 | 0.050 | Aquaporin 8 |
Cell growth | FAM107A | 608295 | NM_007177.1 | 0.040 | Family with sequence similarity 107, member A (TU3A) |
| Â | EMP1 | 602333 | NM_001423.1 | 0.047 | Epithelial membrane protein 1 (growth arrest) |
| Â | BTG1 | 109580 | NM_00173 1.1 | 0.050 | B-cell translocation gene 1, anti-proliferative |
| Â | KLF4 | 602253 | NM_004235.1 | 0.050 | Kruppel-like factor 4 (gut) |