Figure 2

Representative s-CoNSs. Each pair of matched conserved proteins from two different species is shown in one node with their identifiers delimited by a slash; black edges are conserved PPIs existed in both PINs and constitute the s-CoNS, while red/green edges are discrepant PPIs observed only in the species on the left/right of the slash, respectively. a-d. These s-CoNSs corresponds to the RNA polymerase (RNAP) of prokaryotes and are identified from the PIN comparison between E.coli (left) and H.pylori (right) (figure 10). e. This s-CoNS is from the NetAlign analysis between H.sapien and M.musculus. It is a part of the system of fibroblast growth factors (FGF) and FGF receptors (figure 8). Gene duplication present in this system results in great redundancy for the identified s-CoNSs that 151 very similar s-CoNSs are identified. f. This is an s-CoNS harbored by the PINs of S.cerevisiae and C.elegans, and it is a part of E2F/DP transcription factor complex (figure 4). Based on the discrepant red edge, we predict that F11A10.2 interacts with T13H5.4 and this prediction is also present in the interolog database [32]. g-k. These s-CoNSs constitute the complex of replication factor C (figure 3) and are derived from the comparison between the PINs of S.cerevisiae and H.sapien.