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Table 1 Oxyanion hole region for representative sequences of the GGGX class.

From: DWARF – a data warehouse system for analyzing protein families

Family

Accession code

Oxyanion hole region

abH1

1MX1F

KNRLPVMVWIHGGG LMVGAAS

abH2

Q99156

ATNLPVFVWIHGGG NLAGNGY

abH2

50546206

-ARLPTVVWIHGGS NIEGSIY

abH3

1LPS

-ANLPVMLWIFGGG FEVGGTS

abH4

1JJIA

-S--PVLVYYHGGG FVICSIE

abH5

AAC50666

-RSRSLIVHFHGGG FVAQTSR

abH5

CAF98042

-SSPCIVIHFHGGG FVAQTSK

abH6

1JKMA

--VLPGLVYTHGGG MTILTTD

  1. The sequence block was extracted from an alignment of representative GGGX sequences. This alignment illustrates the high similarity within the oxyanion hole region for the families abH2 and abH5 (without protein structure entries), and the remaining GGGX class families which include proteins with known structure. The oxyanion hole forming residue is indicated in bold letters.