Table 1 Performance of HMM-d, HMM-t, HMM-ModE and HMM-Sub for the sub-family classification of the AGC family of kinases.
Methods | HMM-d | HMM-T | HMM-ModE | HMM-Sub | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sub-groups of AGC kinases | Sensitivity | Specificity | Sensitivity | Specificity | Sensitivity | Specificity | Sensitivity | Specificity | ||||||||
GRK | 1 | (0) | 0.27 | (0.03) | 1 | (0) | 1 | (0) | 1 | (0) | 1 | (0) | 1 | (0) | 1 | (0) |
PKA | 0.96 | (0.1) | 0.18 | (0.02) | 0.89 | (0.13) | 1 | (0) | 0.89 | (0.13) | 1 | (0) | 0.96 | (0.07) | 1 | (0) |
PKC | 0.99 | (0.05) | 0.42 | (0.1) | 0.95 | (0.08) | 0.99 | (0.2) | 0.96 | (0.08) | 1 | (0) | 0.97 | (0.06) | 1 | (0) |
PVPK | 1 | (0) | 0.17 | (0.03) | 0.94 | (0.1) | 0.93 | (0.13) | 0.94 | (0.1) | 0.96 | (0.12) | 0.96 | (0.08) | 1 | (0) |
RAC | 1 | (0) | 0.09 | (0.00) | 0.9 | (0.16) | 1 | (0) | 0.93 | (0.1) | 1 | (0) | 0.97 | (0.1) | 1 | (0) |
S6PK | 1 | (0) | 0.14 | (0.01) | 0.98 | (0.08) | 0.98 | (0.06) | 0.975 | (0.08) | 0.98 | (0.06) | 0.93 | (0.24) | 0.98 | (0.06) |