sIR: siRNA Information Resource, a web-based tool for siRNA sequence design and analysis and an open access siRNA database

Table 2 Summary of test set scores

	ANN				siRecords
	Least potent avg score	Most potent avg score	T-test p-value	Correlation between efficiency and Inhibitory activity	Low efficiency avg score	Medium efficiency avg score	High efficiency avg score	Very high efficiency avg score	One-way ANOVA test p-value
sIR	37.9	62.9	5.60E-115	0.422	50.7	57.9	58.3	60	1.51E-18
Amarzguioui	40.8	62.9	4.54E-91	0.34	51.2	58.1	59.1	60	1.51E-18
Ui-Tei	40.3	68.4	2.67E-101	0.39	52.6	60.9	61.8	64	1.84E-18
Rational	21.6	50.3	1.90E-108	0.4	34.7	39.5	40.2	43.8	4.03E-12

This table summarizes the scores attained by ANN (Huesken et al., 2005) and siRecords (Ren et al., 2006) sequences. siRNA scores were computed to compare weighted "sIR" and un-weighted "Rational design", "Ui-tei design" and "Amarzguioui design" scoring systems. This table shows the averages, p-values as well as correlation coefficient values obtained by the siRNA sequences in all four scoring systems.

ISSN: 1471-2105