Figure 2
From: Optimization based automated curation of metabolic reconstructions
Connectivity restoration mechanisms for problem metabolites. In (a), reversing the directionality of a reaction restores the connectivity of metabolite (A) to the network. In (b) reactions are added from the external database to the model organism in order to enable production and consumption of no-production and no-consumption metabolites respectively. In (c), the production of no-production metabolite A is enabled by adding an external uptake pathway, the consumption of no-consumption metabolite B is enabled by adding an external secretion pathway.