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Table 5 Complementarity within the six unique functional site prediction schemes.1

From: Assessing the ability of sequence-based methods to provide functional insight within membrane integral proteins: a case study analyzing the neurotransmitter/Na+ symporter family

 

PM

FPE

SC85

Rate4Site

ET

SDPpred

PM

---

---

---

---

---

---

FPE

0.62

---

---

---

---

---

SC85

0.62

0.69

---

---

---

---

Rate4Site

0.66

0.49

0.59

---

---

---

ET

0.69

0.64

0.62

0.62

---

---

SDPpred

0.80

0.66

0.86

0.71

0.64

---

  1. 1 Complementarity is calculated as the Euclidean distance between each vector pair describing the results within Table 2, meaning each vector has 34 dimensions. Each dimension is simply a binary possibility (1 = predicted functional site; 0 = not predicted functional site). The values reported are normalized such that two completely orthogonal vectors will have a distance of one; two vectors that are absolutely the same will have a distance of 0.00, whereas two completely orthogonal vectors will have a distance of 1.00. The average value and standard deviation across the matrix are 0.66 and 0.09, respectively, which corresponds to 15.0 and 4.1 differences.