Table 4 Protein Kinase Dataset. Detailed SCOP classification for each protein domain in the Protein Kinase (PK) dataset, grouped according to Hanks' and Hunter's (HH) original classification scheme
HH Cluster | Sub Cluster | Protein Domain | SCOP Classification Level | |||||
|---|---|---|---|---|---|---|---|---|
| Â | Â | Â | Class | Fold | Superfamily | Family | Domain | Species |
1 | A | d1apme_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | cAMP-dep. PK, c.s. | mouse |
|  |  | d1atpe_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | cAMP-dep. PK, c.s. | mouse |
|  |  | d1bkxa_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | cAMP-dep. PK, c.s. | mouse |
|  |  | d1fmoe_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | cAMP-dep. PK, c.s. | mouse |
|  |  | d2cpke_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | cAMP-dep. PK, c.s. | mouse |
|  | B | d1cdka_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | cAMP-dep. PK, c.s. | pig |
|  |  | d1cmke_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | cAMP-dep. PK, c.s. | pig |
|  |  | d1ctpe_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | cAMP-dep. PK, c.s. | pig |
|  | C | d1stce_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | cAMP-dep. PK, c.s. | cow |
|  |  | d1ydre_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | cAMP-dep. PK, c.s. | cow |
|  |  | d1ydse_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | cAMP-dep. PK, c.s. | cow |
|  |  | d1ydte_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | cAMP-dep. PK, c.s. | cow |
2 | - | d1ptq__ | small | PK c.-r. domain | PK c.-r. domain | PK c.-r. domain | PK C-delta (PKCdelta) | mouse |
| Â | Â | d1ptr__ | small | PK c.-r. domain | PK c.-r. domain | PK c.-r. domain | PK C-delta (PKCdelta) | mouse |
3 | - | d1phk__ | α + β | PK-like | PK-like | PK c.s. (S/TK) | γ-subunit glycogen Phk | rabbit |
4 | A | d1a06__ | α + β | PK-like | PK-like | PK c.s. (S/TK) | Calmodulin-dep. PK | rat |
|  | B | d1cdma_ | α | EF Hand-like | EF-hand | Calmodulin-like | Calmodulin | cow |
|  |  | d1cm1a_ | α | EF Hand-like | EF-hand | Calmodulin-like | Calmodulin | cow |
|  |  | d1cm4a_ | α | EF Hand-like | EF-hand | Calmodulin-like | Calmodulin | cow |
5 | A | d1lr4a_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | Casein kinase-2, CK2 | maize |
|  | B | d1csn__ | α + β | PK-like | PK-like | PK c.s. (S/TK) | Casein kinase-1, CK1 | fission yeast |
|  |  | d2csn__ | α + β | PK-like | PK-like | PK c.s. (S/TK) | Casein kinase-1, CK1 | fission yeast |
6 | - | d1aq1__ | α + β | PK-like | PK-like | PK c.s. (S/TK) | Cyclin-dep. PK, CDK2 | human |
|  |  | d1fina_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | Cyclin-dep. PK, CDK2 | human |
|  |  | d1hck__ | α + β | PK-like | PK-like | PK c.s. (S/TK) | Cyclin-dep. PK, CDK2 | human |
|  |  | d1hcl__ | α + β | PK-like | PK-like | PK c.s. (S/TK) | Cyclin-dep. PK, CDK2 | human |
|  |  | d1jsua_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | Cyclin-dep. PK, CDK2 | human |
7 | A | d1ad5a1 | β | SH3-like barrel | SH3-domain | SH3-domain | Hemapoetic cell kinase Hck | human |
|  |  | d1ad5a2 | α + β | SH2-like | SH2 domain | SH2 domain | Hemopoetic cell kinase Hck | human |
|  |  | d1ad5a3 | α + β | PK-like | PK-like | PK c.s. (TK) | Hemopoetic cell kinase Hck | human |
|  |  | d1fmk_1 | β | SH3-like barrel | SH3-domain | SH3-domain | c-src protein TK | human |
|  |  | d1fmk_2 | α + β | SH2-like | SH2 domain | SH2 domain | c-src TK | human |
|  |  | d1fmk_3 | α + β | PK-like | PK-like | PK c.s. (TK) | c-src TK | human |
|  |  | d2hcka1 | β | SH3-like barrel | SH3-domain | SH3-domain | Hemapoetic cell kinase Hck | human |
|  |  | d2hcka2 | α + β | SH2-like | SH2 domain | SH2 domain | Hemopoetic cell kinase Hck | human |
|  |  | d2hcka3 | α + β | PK-like | PK-like | PK c.s. (TK) | Haemopoetic cell kinase Hck | human |
|  |  | d2ptk_1 | β | SH3-like barrel | SH3-domain | SH3-domain | c-src protein TK | chicken |
|  |  | d2ptk_2 | α + β | SH2-like | SH2 domain | SH2 domain | c-src TK | chicken |
|  |  | d2ptk_3 | α + β | PK-like | PK-like | PK c.s. (TK) | c-src TK | chicken |
|  | B | d1aotf_ | α + β | SH2-like | SH2 domain | SH2 domain | TK Fyn | human |
|  |  | d1blj__ | α + β | SH2-like | SH2 domain | SH2 domain | P55 Blk protein TK | mouse |
|  |  | d1csya_ | α + β | SH2-like | SH2 domain | SH2 domain | Syk TK | human |
|  |  | d1cwea_ | α + β | SH2-like | SH2 domain | SH2 domain | p56-lck TK | human |
|  | C | d1fgka_ | α + β | PK-like | PK-like | PK c.s. (TK) | Fibroblast growth factor receptor 1 | human |
|  |  | d1ir3a_ | α + β | PK-like | PK-like | PK c.s. (TK) | Insulin receptor | human |
|  |  | d1irk__ | α + β | PK-like | PK-like | PK c.s. (TK) | Insulin receptor | human |
|  |  | d3lck__ | α + β | PK-like | PK-like | PK c.s. (TK) | Lymphocyte kinase (lck) | human |
8 | A | d1erk__ | α + β | PK-like | PK-like | PK c.s. (S/TK) | MAP kinase Erk2 | rat |
|  | B | d1ian__ | α + β | PK-like | PK-like | PK c.s. (S/TK) | MAP kinase p38 | human |
|  |  | d1p38__ | α + β | PK-like | PK-like | PK c.s. (S/TK) | MAP kinase p38 | mouse |
|  |  | d1wfc__ | α + β | PK-like | PK-like | PK c.s. (S/TK) | MAP kinase p38 | human |
9 | A | d1koa_1 | β | IG-like β-sandwich | IG | I set domains | Twitchin | nematode |
|  |  | d1koa_2 | α + β | PK-like | PK-like | PK c.s. (S/TK) | Twitchin, kinase domain | Caenorhabditis elegans |
|  | B | d1koba_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | Twitchin, kinase domain | California sea hare |