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Table 2 Genes involved in drug metabolisms altered by riddelliine treatment in liver

From: Gene expression changes induced by the tumorigenic pyrrolizidine alkaloid riddelliine in liver of Big Blue rats

Gene symbol

Gene description

Locus link ID

Fold change

P-value

Phase I metabolism

   

CYP2C

cytochrome P450, family 2, subfamily c

29277

0.003

0.00000

CYP2C12

cytochrome P450, family 2, subfamily c

25011

41.89

0.00000

CYP2C13

cytochrome P450, family 2, subfamily c

171521

0.002

0.00000

CYP2C22

cytochrome P450, family 2, subfamily c

171518

0.37

0.00000

CYP2E1

cytochrome P450, family 2, subfamily e

25086

2.07

0.00001

CYP3A2

cytochrome P450, family 3, subfamily a

266682

0.002

0.00000

CYP3A9

cytochrome P450, family 3, subfamily a

171352

6.38

0.00000

CYP3A18

cytochrome P450, family 3, subfamily a

252931

0.06

0.00000

CYP4A12

cytochrome P450, family 4, subfamily a

266674

0.20

0.00000

CYP26

cytochrome P450, family 26

154985

11.82

0.00049

Phase II metabolism

   

GSTA3

glutathione S-transferase, alpha 3

14859

11.80

0.00001

GSTM1

glutathione S-transferase, mu 1

24423

0.40

0.00036

GSTM2

glutathione S-transferase, mu 2

24424

0.48

0.00005

Phase III metabolism

   

ABCB1A

ATP-binging cassette, subfamily b (MDR/TAP)

170913

2.65

0.00001

ABCC3

ATP-binging cassette, subfamily c (CFTR/MRP)

140668

10.07

0.00004

ABCC8

ATP-binging cassette, subfamily c (CFTR/MRP)

25559

0.38

0.00001

ABCC9

ATP-binging cassette, subfamily c (CFTR/MRP)

25560

0.47

0.00013

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BMC Bioinformatics

ISSN: 1471-2105

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