Table 4 Genes involved in liver injury and abnormalities altered by riddelliine treatment
Gene | Description | Locus link ID | Fold change | P-value |
|---|---|---|---|---|
* AHR | aryl hydrocarbon receptor | 25690 | 2.03 | 0.0030 |
* EDG5 | endothelial differentiation, G-protein-coupled receptor, 5 | 29415 | 0.19 | 0.0000 |
* EGR1 | early growth response 1 | 24330 | 2.13 | 0.0090 |
F7 | coagulation factor VII | 260320 | 2.22 | 0.0000 |
HGF | hepatocyte growth factor (hepapoietin A; scatter factor) | 24446 | 2.46 | 0.0080 |
* IGFBP1 | insulin-like growth factor binding protein 1 | 25685 | 3.42 | 0.0020 |
* IGFBP2 | insulin-like growth factor binding protein 2 | 25662 | 15.53 | 0.00001 |
* IL11 | interleukin 11 | 171040 | 2.38 | 0.0020 |
* IL15 | interleukin 15 | 25670 | 2.00 | 0.00000 |
* IL7 | interleukin 7 | 25647 | 0.25 | 0.0000 |
* MMP7 | matrix metalloproteinase 7 (matrilysin, uterine) | 25335 | 0.05 | 0.00006 |
* MT1A | metallothionein 1A (functional) | 24567 | 11.10 | 0.0030 |
MTHFD2 | methylenetetrahydrofolate dehydrogenase 2, | 17768 | 0.33 | 0.0060 |
* NQO1 | NAD(P)H dehydrogenase, quinone 1 | 24314 | 2.48 | 0.0030 |
* PPARG | peroxisome proliferative activated receptor, gamma | 25664 | 0.17 | 0.00052 |
* PRKCA | protein kinase C, alpha | 24680 | 2.41 | 0.0000 |
* PRKCZ | protein kinase C, zeta | 25522 | 3.22 | 0.0020 |
REN | renin | 24715 | 4.48 | 0.0010 |
* TGFA | transforming growth factor, alpha | 24827 | 0.36 | 0.0000 |
* TNF | tumor necrosis factor (TNF superfamily, member 2) | 24835 | 0.05 | 0.0000 |
* TNFRSF6 | Fas (TNF receptor superfamily, member 6) | 246097 | 3.34 | 0.0010 |
* TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 246775 | 2.40 | 0.0020 |