Figure 4
A. Gene expression regulations (log2 fold changes) measured by the top 100 mouse probe sets in the CHL2 mouse model of Huntington's disease and their orthologous regulations measured in the brain of human HD patients. The red line is the plot diagonal. In case multiple human probe sets were found for a given mouse probe set, we selected the probe set with the smallest p-value (i.e. detecting the most robust change in HD patients versus controls). Note that the probe set selection method can be specified by the user (see package's vignette). Green and red dots indicate the 5 most significant changes in CHL2 mice showing concordant, respectively discordant regulations in HD patients. B. 88 ortholog pairs (out of the 100 mouse probe sets showing the most significant changes) were classified according to the concordance of HD-related differential expression measures in mice and humans. 'No change' indicate ortholog pairs for which the human gene did not show significant differential expression between HD patients and controls.