Not proper ROC curves as new tool for the analysis of differentially expressed genes in microarray experiments

BMC Bioinformatics

Table 2 Comparison between 14 NBC and 20 heterogeneous lymphomas – genes selected by ABCR and TNRC statistics

N	Gene ID	Gene name	ABCR	TNRC	Group
1	GENE3389X	Immunoglobulin J chain	0.2250	0.2000	1
2	GENE3390X	Immunoglobulin J chain	0.2096	0.1954	1
3	GENE3388X	Immunoglobulin J chain	0.2143	0.1858	1
4	GENE3323X	BCL7A	0.2069	0.1836	3
5	GENE3407X	Histone deacetylase 3	0.2122	0.1694	4
6	GENE75X	VRK2 kinase	0.2015	0.1552	5
7	GENE1141X	MAPKKK5	0.2105	0.1390	5
8	GENE1817X	BL34	0.2171	0.1314	3
9	GENE2395X	Unknown	0.2025	0.1310	Unknown
10	GENE2696X	Unknown	0.2531	0.1224	Unknown
11	GENE3521X	Similar to KIAA0050	0.2051	0.1122	5
12	GENE74X	VRK2 kinase	0.2043	0.0954	5
13	GENE2287X	MRC OX-2	0.2046	0.0940	1
14	GENE3541X	Unknown	0.2436	0.0900	Unknown
15	GENE1362X	Syndecan-2	0.2031	0.0816	5
16	GENE2673X	Unknown	0.2034	0.0816	Unknown

Group 1: lymphocyte/macrophage related genes; Group 2: major histocompatibility complex related genes; Group 3: genes involved in malignant cell transformation; Group 4: genes related to nucleic acid metabolism or DNA transcription; Group 5: genes encoding various enzymes/kinases and other proteins. ABCR: Area between the ROC curve and the rising diagonal; TNRC: Test for not-proper ROC curves.

ISSN: 1471-2105