Not proper ROC curves as new tool for the analysis of differentially expressed genes in microarray experiments

BMC Bioinformatics

Table 3 Comparison between 14 NBC and 20 heterogeneous lymphomas – top 16 genes selected by ABCR and AUC statistics

N	Gene ID		Gene name	ABCR	AUC	Group
1	GENE2495X	+	Unknown	0.5000	1.0000	Unknown
2	GENE1217X	-	NFkB2	0.5000	0.0000	4
3	GENE1602X	-	protein kinase (zpk)	0.5000	0.0000	5
4	GENE1191X	-	CREM	0.5000	0.0000	4
5	GENE1171X	-	Similar to spi-1	0.4964	0.0036	3
6	GENE1219X	-	IkB alpha	0.4964	0.0036	4
7	GENE3795X	+	AIM2	0.4964	0.9964	1
8	GENE1730X	-	Sgk	0.4929	0.0071	5
9	GENE1170X	-	CD83	0.4929	0.0071	1
10	GENE3702X	+	Unknown	0.4893	0.9893	Unknown
11	GENE2494X	+	Unknown	0.4857	0.9857	Unknown
12	GENE3280X	+	eIF-2B alpha subunit	0.4857	0.9857	4
13	GENE1160X	-	Unknown	0.4857	0.0143	Unknown
14	GENE589X	-	eIF-3	0.4821	0.0179	4
15	GENE1172X	-	CD83	0.4786	0.0214	1
16	GENE324X	-	Nak1	0.4786	0.0214	5

Group 1: lymphocyte/macrophage related genes; Group 2: major histocompatibility complex related genes; Group 3: genes involved in malignant cell transformation; Group 4: genes related to nucleic acid metabolism or DNA transcription; Group 5: genes encoding various enzymes/kinases and other proteins. ABCR: Area between the ROC curve and the rising diagonal; AUC = Area under the ROC curve; "+" = overexpressed; "-" = underexpressed.

ISSN: 1471-2105